On Friday morning, head coach Doug Pederson officially announced that running back Darren Sproles (concussion) and tackle Halapoulivaati Vaitai (knee) are both out for Sunday's game against Baltimore.
Without Sproles, the Eagles will keep rookie running back Byron Marshall active. Marshall has spent the entire season on the practice squad before being elevated to the active roster earlier this week.
Meanwhile, OL Allen Barbre (hamstring) and WR Jordan Matthews (ankle) are questionable heading into Sunday.
As a precaution, the Eagles practiced with rookie third-round pick Isaac Seumalo at right tackle while Barbre recovers. If everything goes to plan, Stefen Wisniewski will start at left guard, Brandon Brooks will start at right guard, and Barbre will start at right tackle with Seumalo as an insurance policy. Brooks has returned to practice after missing Sunday's game with an illness.
The good news for the offensive line is that Lane Johnson is able to return from his 10-game suspension on Monday and will hopefully be ready to play in the Eagles' final two games of the regular season.
For Baltimore, starting cornerback Jimmy Smith has been dealing with an ankle injury and is officially out for Sunday's game. TE Crockett Gilmore (thigh), DB/LB Anthony Levine Sr. (toe), and CB Jerraud Powers (concussion) are all questionable.
Check out the full injury reports from both teams here.