Marisa Pilla, Ike Reese, and Fran Duffy provide instant reaction and analysis of the Eagles' loss to the 49ers. Plus, hear from Head Coach Nick Sirianni, quarterback Jalen Hurts, defensive tackle Fletcher Cox, and defensive end Brandon Graham.

Following the loss to the 49ers, go inside the locker room and hear from Fletcher Cox, Brandon Graham (3:39), A.J. Brown (9:20), and James Bradberry (15:11).

Head Coach Nick Sirianni shared his perspective of the Eagles' loss to the 49ers on Sunday at Lincoln Financial Field.

Jalen Hurts spoke with reporters following the Eagles' loss to the 49ers. The quarterback explained what happened in the fourth quarter when he was evaluated for a concussion.

Watch Eagles wide receiver A.J. Brown's best plays from his 114-yard game against the San Francisco 49ers.

Eagles quarterback Jalen Hurts' 2-yard TD pass to DeVonta Smith trims 49ers' lead to 35-19.

Eagles quarterback Jalen Hurts has an eternity to locate running back Boston Scott for a 27-yard connection on third down.

Eagles quarterback Jalen Hurts rushes for a 1-yard touchdown vs. San Francisco 49ers, the 100th total touchdown of his career.

Eagles quarterback Jalen Hurts' chain-moving pass dots wide receicer A.J. Brown as Nick Bosa chases QB down.

Philadelphia Eagles wide receiver DeVonta Smith zips through defenders on 21-yard pickup.

Philadelphia Eagles quarterback Jalen Hurts sneaks fastball JUST past San Francisco 49ers DB for 11-yard gain to wide receiver DeVonta Smith.

Eagles quarterback Jalen Hurts' second connection with wide receiver A.J. Brown yields 17-yard pickup.

Kicker Jake Elliott's 26-yard field goal caps Philadelphia Eagles' 12-play opening drive vs. San Francisco 49ers.

Philadelphia Eagles quarterback Jalen Hurts and wide receiver A.J. Brown connect for 38-yard gain on Eagles' third play.

Ross Tucker lays out his three keys to an Eagles win today as the 49ers come to Lincoln Financial Field for a rematch of the NFC Championship Game in a showdown that will loom large as the playoff picture unfolds. Make sure to order your Little Caesars before kickoff!

The Eagles have found a way to win just about every week this season by being the tougher team, the longer against some of the NFL's best. They'll need to dig down deep once again as the San Francisco 49ers come to town looking for revenge after last season's 31-7 loss in the NFC Championship Game.

Wide receiver DeSean Jackson will be honored as the Honorary Captain this Sunday when the Eagles host the San Francisco 49ers. Jackson joined Eagles Insider Dave Spadaro for the Microsoft Teams Legend of the Week interview to explain why he decided to officially retire this week as a Philadelphia Eagle.

It's more than a rematch of the 2022 NFC Championship Game. Sunday's showdown between the San Francisco 49ers and the Philadelphia Eagles will go a long way in determining the No. 1 seed in the NFC. Join John Clark, Mike Quick, Ike Reese, Greg Cosell, and Fran Duffy for the most in-depth breakdown of this week's must-see matchup!

Brandon Graham set the Eagles' record for most regular-season games played last Sunday during the thrilling overtime win against the Bills. Graham reflects on his journey from a first-round draft pick in 2010 to now and how his family has supported him to become one of the most beloved players in franchise history on the latest Eagles Unscripted, presented by Lincoln Financial Group.

Following the final practice ahead of Sunday's game against the 49ers, tight end Dallas Goedert discusses his chances of playing and cornerback Darius Slay (4:22) explains whether this is one of the up-and-coming rivalries in the league.

DeSean Jackson, one of the most dynamic playmakers in NFL history, signed a ceremonial contract to retire as an Eagle on Friday. On his 37th birthday, Jackson recalls what made Philadelphia such an integral part of his career.

Eagles Passing Game Coordinator/Associate Head Coach Kevin Patullo joins Fran Duffy on this week's Tape Study, presented by Chickie's and Pete's, to examine the film of quarterback Jalen Hurts' three biggest passes from the overtime win against Buffalo.

Head Coach Nick Sirianni shares why he's confident in the depth at the linebacker position entering Sunday's clash with the 49ers and how DeSean Jackson is a part of his teaching process even though the two never worked together.

The last two top draft picks headline Thursday's trip around the locker room ahead of Sunday's clash with the San Francisco 49ers. Hear from Jordan Davis, Haason Reddick (4:03), A.J. Brown (5:12), and Jalen Carter (11:11).

Watch and listen to all the best moments of the Philadelphia Eagles' game against the Buffalo Bills in the newest episode of Eagles Mic'd Up. Join defensive end Brandon Graham as he celebrates his franchise record for the most regular-season games played. Watch everything from Graham's perspective as he plays in one of the most exhilarating overtime wins. Don't miss this exciting episode of Eagles Mic'd Up, presented by DraftKings!