After being listed as questionable for today's game, both 49ers starting right tackle Trent Brown (concussion) and linebacker Reuben Foster (ankle, ribs) have been ruled out against the Eagles. Right tackle Garry Gilliam and linebacker Brock Coyle will start in their place. 49ers right guard Brandon Fusco was also listed as questionable but will play.
For Philadelphia, second-year lineman Halapoulavaati Vaitai will start at left tackle in place for Jason Peters who was placed on Injured Reserve last week.
Listed as inactive for the Eagles include: CB Ronald Darby , WR Shelton Gibson, DT Justin Hamilton, T Taylor Hart, LB Jordan Hicks, DE Steven Means, and DT Elijah Qualls.
For the 49ers, WR Victor Bolden Jr., CB K'Waun Williams, DB Dexter McCoil, LB Pita Taumoepenu, LB LB Reuben Foster, DL Aaron Lynch, and OL Trent Brown are listed as inactive.